It has an excellent photo stability and safety profile. Moisturizer, or emollient, is a cosmetic preparation used for protecting, moisturizing, and lubricating the skin. Skin Care Products SOS Organics 5. Of course, the quality of a finished product is the ultimate objective of a company; this is also what the consumers expect from the product. These response statistics, collected from the ESO EMS Index of real-world data, were shared with EMS1 by the ESO data analysis team to continue a discussion about the prehospital assessment and treatment of hypoglycemia, a common consequence of diabetes. Preparation of the cream s containing olive leaf extract. The natural baby skin-care products or methylbenzene. Becoming an expert user 3. The Global Skin care Industry. Buy 1 get 2nd 1/2 Price on selected Superdrug Skin brands. Apply sterile gloves if patient has open lesions: 8. Factors requiring consideration of lower insulin dosing include low body weight, known insulin sensitivity, and underlying renal and liver disease. The Objective present paper focuses on the formulation of completely herbal moisturizers, their evaluation and comparison with commercial moisturizer. Hair: Basic structure of hair. 27 Best Anti-Acne And Anti-Pimple Creams Available In ... Formulation and Evaluation of Moisturizer Containing ... Moisturizers 101: The INCI. The Role of Moisturisers in Skincare - Aesthetics Skin is composed of three main layers: the epidermis, the dermis, and the hypodermis (also known as subcutaneous tissue). by Melody M. Bomgardner. Part A. Hydrophilic-Lipophilic Balance - an overview ... Mix plain water to dried neem powder and allow it to soften for 15 minutes before applying. 100% alcohol free. ABOUT AUTHOR: Vinay Kumar Singh General Manager-Technical, Mikasa Cosmetics Limited, Ahmedabad, Gujarat vinay.s@mikasacosmetics.com Quality does not merely mean the goodness of a finished product. (PDF) An extensive review of face powders: Functional uses ... An exception to this rule is that in the US, for … However, EOs have a short shelf life, as they are volatile and reactive in the presence of light, heat, moisture and oxygen. Frontiers | Role of Nanotechnology for Design and ... These static images can easily be manipulated and magnified to detect changes in progression or improvement in diabetic eye disease. Contains emollients (moisturizers) for skin hydration and to form a protective barrier. Moisturizer Formulas 1 Vitaminized A.M. Cream (No. ... 2 Frosting Cream (No. 1447) Properties : Keep your skin hydrated and nourished all winter long with this thick, luxurious frosting cream. 3 RosenCreme (No. ... 4 DD Cream (No. ... 5 Hydrating Cream for the Mature Skin with Hyaluronic Acid & Ceramide Complex (No. ... 6 Shave Cream (No. ... 7. Normal human blood glucose levels remains within a remarkably narrow range.|In most humans this varies from about 82 mg/dl to 110 mg/dl (4.4 to 6.1 mmol/l). skin.”5 Controlled in vivo studies demonstrate that moisturizers can treat skin dryness and prevent its return, prompting researchers to undertake a home-use study of moisturizers in patients with eczema.6 The home-use study results confirmed the benefits of a moisturizer for reducing skin dry-ness and irritation in eczema. Base cream containing water and oil phases was prepared. Aveeno Skin Relief Hand Cream 75ml Save 1/3 on selected Aveeno…. Panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial JAMA. Top 12 Products. Cost-plus pricing —simply calculating your costs and adding a mark-up. Apply moisturizer after bath to overcome dryness of skin.|In Diabetic foot: Who should view this course? At least 30 minutes of exercise in the morning can prevent and get rid of dark circles. Don't you just love those pictures of vintage suitcases stacked one on top of the other. Brian explained that a good way to evaluate your growth is to take away all other forms of your marketing strategy — this means emails, paid ads, anything that promotes your product — and see whether your company continues to grow. 1. diabetesusedmedications prognosis 3) Should melt or soften on application to the skin 4) Should spread easily without too much of drag. film former which will give longevity to any formulation Formulation and Evaluation of Exotic Fat Based August 22nd, 2016 - Formulation and Evaluation of Exotic Fat Based Cosmeceuticals for Skin Repair The pre formulation studies and product optimization was carried out with respect to quantity of mango butter and olein 43. Cosmetic Formulation of Skin Care Products - ANME Gel moisturizer formula provides hydration to skin, leaving it looking smooth and supple day after day. The Types of Moisturizers Explained: How to Choose Your ... diabetesusedmedications essay. If you need a refresher of basic formulation knowledge you can start with Formulating 101 our welcome packet, so to speak, which contains handy reference guides on formulating essentials. Punjabi University, Patiala | Higher Education Institute ... The Natural Cosmetic Formulation Club is a global network of like-minded natural and organic cosmetic formulators, a space where you can enhance and diversify your skills and knowledge.. Polymeric nanoparticles within a size range of 10–1000 nm provide delayed and controlled release of lipophilic drugs by increasing the adhesivity and duration time of the drug in the skin (Uchechi et al., 2016). FORMULATION OF VANISHING CREAM • Ideal formula Ingredients Quantity (%w/w) Category Oil Phase Stearic acid,triple pressed 15.0 % Cetyl alcohol 0.50 % Emollient, water-absorptive, and emulsifying properties Isopropyl myristate 3.00 % Nongreasy emollient Aqueous Phase Sodium Hydroxide Potassium Hydroxide 0.18 % 0.50 % Alkali Alkali Glycerol … Also known as "balm", "salve", and "unguent". The thirtieth book in this series, Cosmetic Formulation of Skin Care Products edited by Zoe Diana Draelos, MD and Lauren Thaman, MS comprises 22 chapters authored or co-authored by over 30 experts in the field. Discuss in detail the formulation of vanishing cream and cold cream. Lotions may still be a … I Painted and Stenciled My Ceramic Tile! Whereas HbA 1c remains the main glycemic indicator used to determine the success of diabetes treatment (2,9,10), a recent result often is not available during patient visits to guide adjustment of therapy.Rapid-turnaround HbA 1c methodology is commercially available, but such determinations are not widely used in outpatient practice … Add fragranceat 45°c. Mix plain water to dried neem powder and allow it to soften for 15 minutes before applying. Using patents to get you started 5. Download Full PDF Package. Oil in water emuls ion. February 10, 2014 | A version of this story appeared in Volume 92, Issue 6. This skin care formulation fluid contains natural and organic certified skin care ingredients and helps to strengthen the skin’s natural hydrolipidic barrier for healthy-looking skin. A light emulsion skin care formulation for Asian skin to provide a bright and even skin tone. 6. sunflower wax al one and in combination of both. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders and infections such as acne, seborrheic dermatitis, eczema, psoriasis, corns, calluses, and warts. If you have normal, dry, or sensitive skin, you may find that cream-based moisturizers provide the right hydration. £1.99 £1.33 per 100ml. oz. 54. Mix plain water to dried neem powder and allow it to soften for 15 minutes before applying. This body pack may cause dry skin. Occlusive. Pricing a product is one of the most important aspects of your marketing strategy. Nanotechnology is an innovative science that includes the design, characterization, production and application of structures, devices and systems by controlling shape and size at the nanometer scale, which covers the size range from 1 nanometer to 100 nanometer (nm), where 1 nanometer is 1 billionth of a meter. The purpose of this activity is to enable the learner to acquire a better understanding of the field of oncology nursing, outlining the role, responsibilities, and professional performance of the oncology infusion nurse in the administration of chemotherapy. Dried neem powder can be used if fresh neem leaves are not available. [2] The word "emollient" is derived from the Latin verb mollire , to soften. Analyzing the ingredient list 4. Dried neem powder can be used if fresh neem leaves are not available. One of such dressings, Polymem, is available in XY hospital. They believe that adding an additional layer onto the skin will only make matters worse in terms of skin grease. Apply moisturizer after bath to overcome dryness of skin.|In Diabetic foot: In the range of 3.5 to 6.0, surfactants are more suitable for use in W/O emulsions. Pediatric skin is thinner and better hydrated, which enhances topical drug absorption and potential drug toxicities. Face Moisturizer with Squalane and Watermelon Extract (No. Applying while skin is damp helps to retain moisture within skin layers. Moisturizers Moisturizers are complex mixtures of chemical agents often occlusive help hold water in the skin after application, humectants attract moisture and emollients help smooth the skin. Barel, Paye, Maibach - Handbook of Cosmetic Science and Technology Cool while mixing to 50°c. Further all of the prepared formulation and selected … It is regarding the usage pattern of skin care products in very also listed on labels as benzene, toluol, phenylmethane, young children. Describe the structure and functions of the skin with neat labeled diagram. The diagnosis of peripheral neuropathy was based on clinical signs and symptoms, in addition to insensitivity of the foot to 10-g Semmes-Weinstein monofilament [], loss of vibration perception tested by using a 128-Hz tuning fork on the medial malleolus and the … 5) Its physical action on skin & pore openings should be that of flushing rather than absorption ... Low blood sugar occurs when the sugar (glucose) … … Hair cosmetics are an important tool that helps to increase patient's adhesion to alopecia and scalp treatments. However, with the improvement of consumers’ education level and the heat of ingredients science, brands put an emphasis on skin science based on ingredients formulation during the promotion. Dermatology Clinics & Research DCR, 5 (1): 238-271 www.scitcentral.com ISSN: 2380-5609 Review Article: Open Access Skin Care Creams: Formulation and Use AK Mohiuddin* * Department of Pharmacy, World University of Bangladesh, Dhaka, Bangladesh. Use a good happinesslifetime.com eye cream product. 3 As well as … Dried neem powder can be used if fresh neem leaves are not available. This body pack may cause dry skin. Dried neem powder can be used if fresh neem leaves are not available. Prevents the escape of moisture. The face powder was demanded by many nations in the world in the beginning AD and in Asia white skin was believed to be the sign of aristocratism, membership of the elite, and yet, white color is the pure symbol of the internal beauty and nobility. Highlighting functional changes in the structure of the epidermis and the stratum corneum, this book presents overviews of clinical and consumer testing approaches together with ex vivo evaluation procedures. It’s about flipping the script on the one-dimensional standard of beauty,” claimed the vice president of CoverGirl, Ukonwa Ojo. They are further explained in the subsequent pages. This label lists the ingredients, by INCI (International Nomenclature Cosmetic Ingredient), in the order of percentage inclusion in the formulation (in most markets). 5. Enhance skin conditioning with formulation do’s & don’ts and expert guidance based on real-world formulations. 4. To help you with that, I have made a list of the top rated anti-acne and anti-pimple creams that are available in India. 2) Should be stable &have good appearance. CHEMISTRY OF SUNSCREEN By: Ally Bateman 2. Dried neem powder can be used if fresh neem leaves are not available. Check Price. Translate PDF. 14. what is a natural cure for diabetes So, with this week being National Diabetes Week, we have seven natural ways to help reduce your blood sugar. Skin: Basic structure and function of skin. The hypodermis anchors skin to muscles, and also contains fat, but it’s slightly less important to our discussion. 2015;314(20):2137-46. Eat certain food groups first. In this tutorial we will walk you through how to make a natural lotion, cream, body butter and moisturiser from scratch. Skin care products include cleanness facial masks, loners, moisturizers, sunscreen, tanning sets and lotions, skin lighteners, serums and exfoliants. Cambridge dictionary defines the … Nearly 10 percent of the U.S. population (30.3 million people) has … Hydrophilic–lipophilic balance (HLB) is the balance of the size and strength of the hydrophilic and lipophilic moieties of a surfactant molecule. Skin-toning (25%) was the least favorite quality. Here is a quick summary of the 10 steps. Similarly, data show 500 g. 2 cups. Writing Committee for the Diabetic Retinopathy Clinical Research Network; Gross JC, Glassman AR, Jampol LM, et al. A Boring Dresser Gets an Epic Suitcase Makeover. Apply this paste as body pack and wash it off after 20 minutes. The Process. However justified and logical this belief is, it is a common misconception that only people with dry skin need to apply moisturizer on a regular basis. But the good news is, you can banish this unwelcome guest easily. Skin temperature and BTMs (measured monthly for first 3 mo and then at 6 mo) were used for monitoring the course of treatment. 1. These ingredients are often greasy and are most effective when applied to damp skin. diabeticdieteggs kidney. Mortality risk is higher for adults admitted to the hospital with both diabetic ketoacidosis and hyperosmolar hyperglycemic state, than for those presenting with either condition alone, and this risk can be exacerbated if severe hypokalemia or hypoglycemia occur, according to findings published in Diabetes Care. 5.1.3.2. This skin care cream formulation contains the active ingredient RETINOL GS 50. If skin is very dry and flaking, apply topical medication while skin is still damp. There are reduced side effects and toxicity to other organs compared to systemicmedications. Skin reflects origin, lifestyle, age and state of health. The demographic data and duration of diabetes were recorded. Preparation: Procedure: Combine and heat phase A, to 75°c. Apply this paste as body pack and wash it off after 20 minutes. 1) Be able to effectively remove oil soluble & water soluble soil, surface oil from skin. 3. Colored make-up preparations: Lipsticks, Rouge, Mascara and Eye-liner. FORMULATONS. pes statements for type 2 diabetes education. Discuss the role of Neem and Clove in oral care formulations. In general terms, “moisturization” (or skin … Aesthetic considerations, such as fragrance, color, packaging and product £4.99 £2.50 per 100ml. Atrixo Intensive Protection Cream 200ml. ). Decode the science behind selecting the right classical ingredients for your moisturizer’s formulation fulfilling consumer’s demand for long-lasting skin hydration, reduced flakes, reduced blemishes, and much more... Water in the skin . Function. 7. Main benefits: Moisturizes, adds shine, protects hair, protects from breakage and increases elasticity 2. Who should use it: In general, full strength argan oil can be used on thicker or curly hair, while lighter versions can be used on all hair types. 2. cream was … Small size and spherical shape of fullerenes made them suitable candidates for use in sunscreens, moisturizers, long-lasting make up. medical definition of diabetes type 1 mellitus nature reviews. Taking this in to consideration, the team chose to assess the effectiveness of facial moisturisers by taking measurements for 30 pre-defined facial sites using digital imaging technology. Competitive pricing—setting a price based on what the competition charges. random blood sugar 126 blood sugar after eating. Keep glucose tabs or other quick carbs handy at your bedside, in your pocket or ...But missing a dose of insulin can cause a rapid rise in blood sugar levels. Generally, pricing strategies include the following five strategies. A variety of skin care products exist in market. Check it out. ALOEVERA AND ALMOND OIL LOTION almond oil ½ cup Beeswax ¾ ounce aloe vera gel 1 cup essential oils (lime) 10 drops vitamin E oil 1 tsp. A Southern California entrepreneur, Kili Anderson co-founded Skin And Senses and has developed a full lineup of cruelty-free products that naturally nourish and heal the skin. % of total. Apply moisturizer after bath to overcome dryness of skin.|In Diabetic foot: The SlideShare family just got bigger. 3. The ad read: “Amy’s skin happens to have variations in tone, and it’s equally as beautiful as the skin we’re used to seeing in beauty ads. Methods Three of the herbal moisturizers [M1–M3] formulated by using in varied concentrations [0.139–0.9%w/w] of herbal extracts, juice and gel. Ingredients, formulation and product viscosity differ widely, however, a typical manufacturing process breaks down into four individual operations: Preparation of the oil phase. 1017) Properties: Moisturizer that contains squalane emollient that has a high affinity to skin cells due its skin-identical structure and is therefore well tolerated by the skin, it is present in human sebum at a level of about 10%, it is nonirritating and hypo-comedogenic. Dyspareunia, recurrent or persistent painful sexual intercourse, is common and can affect women's mental and physical health and relationships. Nanotechnology incorporation in cosmetic formulation is considered as the hottest and emerging technology available. Introduction Sunscreen is a chemical compound that helps protect you from UV rays the sun puts off We can see visible light reflected by the sun and the infrared radiation the sun gives off can be felt on our skin when we get hot (Jaworek-Lopes Sittenfeld 12) 3. They fulfil a variety of functions by either acting directly on the skin (moisturizers) or being a cosmetically elegant vehicle for the delivery of specific active ingredients (sunscreens or anti-acne medicaments). compositions and the a mounts of the formulation i … Apply moisturizer after bath to overcome dryness of skin.|In Diabetic foot: The outer layer of the skin is the stratum corneum; it comprises mature keratinocytes and on average is 15 cell layers thick. Skin also has a role in vitamin D production and absorption. In the ingredient-based skincare consumption in China, based on the modern medical theory, overseas brands occupied a major share of the market. Dried neem powder can be used if fresh neem leaves are not available. 13. 3. An odorless, off-white powder, PARSOL® HS is water soluble on neutralization and thus compatible with most cosmetic ingredients. Describe the principle building blocks used in the formulation of oral care products. The HLB scale ranges from 0 to 20. Mix plain water to dried neem powder and allow it to soften for 15 minutes before applying. Effects on skin exposure to UV and gamma radiation: Aloe vera gel has been reported to have a protective effect against radiation damage to the skin. But if you’d like a calculator which does the work for you CLICK HERE (instructional videos are at the end).. Lotions, creams, body butters and moisturisers are all emulsions and are made the same way with mostly the same ingredients. Oral Cavity: Common problem associated with teeth and gums. £4.32 was £6.49 £5.76 per 100ml. Skin acceptability of a cosmetic moisturizer formulation in female subjects with sensitive skin Stephanie J Nisbet Skin Health Medical Affairs, GSK Consumer Healthcare, Weybridge, Surrey, UK Purpose: This 3-week, open-label, noncomparative clinical study evaluated the skin acceptability of a cosmetic moisturizer in subjects with sensitive skin, by … Neutrogena Hydro Boost Hyaluronic Acid Hydrating Water Face Gel Moisturizer for Dry Skin, 1.7 fl. Skin care remains the most important category in the global beauty market, accounting for 23% value share of total sales in 2009 29. Formulators , R&D managers , technicians , sales & marketing people in charge of skin care products and working with ingredients like moisturizers, humectant ingredients and emollients. type 2 diabetes behavior problems Be Prepared for Panic: Memorize how many grams you need for rapid treatment. The researchers took measurements to determine the skin hydration and transepidermal water loss (TWEL) at each of the sites using digital imaging technology. Massage Cream Formulation [158] INGREDIENT. Skin color, tone and evenness, pigmentation, as well as skin surface characteristics are signs of skin’s health. The. Nine patients with renal insufficiency, i.e., serum creatinine > 120 µmol/L, were also included. Age-related factors affect the epidermis and dermis. We would like to show you a description here but the site won’t allow us. PDF. A small study ...This is because it can help to lower your blood glucose and reduce your risk of other complications. Not all happinesslifetime.com eye creams out in the market can get rid of this skin problem. To a lesser degree Sun Protection Filter (31%), Skin Brightening, and Anti-aging (31% each) were the next favorite qualities in facial moisturizers. Argan Oil. 6. This body pack may cause dry skin. The active ingredient vitamin E acetate is a potent … Extending Shelf Life With Natural Preservatives. This body pack may cause dry skin. Add slowly, phase B to phase A, while homogenising. Because it leaves a dry touch on the skin, PARSOL® HS is specifically recommended for light feel day care products and sunscreens. Occlusives increase the water content of the skin by slowing the evaporation of water from the surface of the skin. This article reviews the formulations and the mode of action of hair cosmetics: Shampoos, conditioners, hair straightening products, hair dyes and henna; regarding their prescription and safetiness. Due to the word toiletry, we misunderstood the concept of toilet soap. Formulation considerations, preparation, packaging and evaluation of the following cosmetic preparation: 1. Baby skin may be soft and smooth, but it’s also more sensitive than skin that's just a year or two older 1. Continue homogenising for a 5 minutes. This study was carried out to formulate a cream for the purpose of nourishing, lightening, antiwrinkle, moisturizer, wound healer and antimicrobial activity. 20. The skin care market consists of the retail sale of facial care, body care, sun care, hand care, depilatories and makeup remover products. Mix plain water to dried neem powder and allow it to soften for 15 minutes before applying. Principles of formulation and building blocks of skin care products: Moisturizer Ingredients - Occlusives. Polymem also promotes formulation of granulation tissue (McGuckin, et al. Moisturizing lotion 1 MOISTURIZING LOTION 2 DEFINITION Moisturizers or emollients are complex mixtures of chemical agents specially designed to make the external layers of the skin softer and more liable. 3 • They increase the skin's hydration (water content) by reducing evaporation. ... More items... It improves appearance of lines and wrinkles, reduces skin photo -damage effects and improves firmness. Some people who suffer from oily skin stay away from moisturizers of any kind. Hair growth cycle. The blood sugar levels rises to nearly 140 mg/dl (7.8 mmol/l) or a bit more in normal humans after a full meal. Greencure Acnesilk Herbal Anti Acne Cream. A Patio Transformation. Change gloves, performing hand hygiene in between. It exerts a keratolytic activity. Obtaining samples 2. Answer (1 of 4): Toilet soap is the soap used as a toiletry and the toiletry means - an object or cosmetic used in making up, dressing, etc. These functions are normally performed by sebum produced by healthy skin. They are used in skin care cosmetics such as creams and milky lotions and to control moisture loss from the skin and improve the feeling on use. Not unusual if 0% water. The term “Moisturizer” resonates with the consumer and denotes improvement of skin, thus projecting the perception of healthy skin. Face Preparation: Face powder, Compact powder, Talcum powder, Face packs and Masks. The artificial or herbal substances found in skincare formulation that helps the health, texture, and integrity of dermis, moisturizing and preserving the … 55. cream formulation based on trieth anolamine using stearic ac id and. Check Price. UNIT II 10 Hours. Hyaluronic acid, a hydrator found naturally in the skin, attracts moisture and locks it in. Apply this paste as body pack and wash it off after 20 minutes. 3 The structure of the stratum corneum has frequently been described as similar to ‘bricks and mortar’; the keratinocytes being the ‘bricks’ and lipids and amino acids making up the majority of the ‘mortar’. Heating may be required to melt some ingredients. Flake/powder ingredients, sometimes dry blended in advance, are dispersed into mineral oil or silicone oil. Toluene is a toxic chemical market is a $1.7 billion industry, little is known commonly found in nail products and hair dyes. This body pack may cause dry skin. Apply this paste as body pack and wash it off after 20 minutes. Among cosmetics, the EOs are mainly used in perfumes, and skin and hair care products 23. Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4 (OH)2. Apply moisturizer after bath to overcome dryness of skin.|In Diabetic foot: Retained on the skin for prolonged periods. O3+ Dermal Zone Zitderm Cream. Ointments have a higher concentration of oil (80%), compared to creams and lotions. type 2 diabetes and skin tags early symptoms. Skin temperature reduced significantly at 3 mo without much inter-group difference. Save 1/3 on selected Aveeno. Next Generation Skin Moisturizer Samares C Biswas, Ph. One reason is because babies have a thinner stratum corneum, which is the outmost layer of dead skin cells that helps protect the body from external irritants. Check Price. A skin lotion is a pseudo-stable mixture of oils and water. Your medicine may need to be adjusted or changed. This fracturing of the commercial skin-care market which began with the introduction of stearate (vanishing) creams in 1892, picked up pace in the 1920s and 1930s and eroded the prestige of cold creams and pushed them increasingly into … Mix plain water to dried neem powder and allow it to soften for 15 minutes before applying. D. 1 ... (5% w/v) 0 20 40 60 80 100 10 mins 2 hours 4 hours Time %Improvementover Baseline PositiveControl Formulation Over a period of 4 hours, amino acid showed better efficacy than 5% glycerol (w/v) Samares C Biswas, Ph. The cosmetic and pharmaceutical industry offers a vast armamentarium of skin care products and procedures to clean, soothe, restore, reinforce, protect and to treat our skin and hence to keep it in “good … Fundus photography is still a crucial tool in the education and management of DR. Cosmetic manufacturers use … Elderly skin is drier, thinner, and more friable, which may predispose to external insults. The oils are used to provide moisturization to skin. Perfume (odour) 0.5 g. Text book of Cosmetic Formulations. Use sterile gloves for open skin lesions to prevent spread of microorganisms. Skin Moisturization. The product contains a wound cleanser, a bacteriostatic, a moisturizer, and an absorbing agent which absorbs ten times its own weight in exudate. time you’ve completed step 10, you’ll have a product formulation that performs almost identically to the one you copied. Day care products, compared to creams and lotions gloves if patient has open:. Will only make matters worse in terms of skin grease on top of other. Problem associated with teeth and gums Ceramide Complex ( No dried neem powder and allow it soften! Renal insufficiency, i.e., serum creatinine > 120 µmol/L, were also included terms of skin adding a.... Fundus photo image captures 30˚ of the skin, thus projecting the perception of healthy skin and evenness pigmentation... 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