Hu ML, Zheng G, Lin H, Yang M, Zhang YD, Han JM. Arginine, Calcium Carbonate, Aqua, Sorbitol, Aroma, Poloxamer 407, Sodium Monofluorophosphate, Cocamidopropyl betaine, Zinc oxide, Benzyl Alcohol, Cellulose Gum, Zinc Citrate, Sodium Bicarbonate, Tetrasodium Pyrophosphate, Xantham Gum, Sodium Saccharin, Sucralose, Limonene, CL77891, 1. Colgate SENSITIVE INSTANT Relief Repair & Prevent toothpaste provides instant* and long-lasting sensitivity relief and lasting gum protection: PRO-ARGIN Technology repairs sensitive areas of the teeth for instant and long-lasting pain relief1,2, Zinc helps to strengthen gums and to prevent recession a key cause of sensitivity3. Based on the outcomes of previous systematic reviews and meta-analysis, the rationale of the present study was to substantiate the claim of immediate pain relief after one-minute application in DH by non-invasive surface application of OTC dentifrices containing Pro-arginin Colgate Sensitive Pro-Relief, and 8% strontium acetate in Sensodyne Rapid Action and other objective was the comparative evaluation of the clinical efficacy of three technologies, BAG-based FCPS in BioMinR F, Pro-argin, and 8% strontium acetate at efficacy intervals of day three, week two, four and six for sustained inhibition of painful stimulus provoking DH as all three are dentinal tubular occluding dentifrices. Hu M-L, Zheng G, Zhang Y-D, Yan X, Li X-C, Lin H. Effect of desensitizing toothpastes on dentine hypersensitivity: a systematic review and meta-analysis. See patient relevant information on Colgate.com. Hu et al. The next study outcome of our study wasrelated to 8% strontium acetate with clinical reduction of 37.6% on SCASS and 46% on VAS from baseline using mechanical and water jet stimuli immediately after topical application on sensitive teeth as depicted in Tables 3, 5, and 6. Helps restore natural whiteness of teeth. Naturally, the researchers wondered whether it could help shield a person from acquiring the virus. This clinical trial was approved by the Institutional Review Board of Dow University of Health Sciences (Ref: IRB-1351/DUHS/Approval/2019/184) and was registered under the protocol ID NCT04249336 (https://clinicaltrials.gov/ct2/show/NCT04249336) on January 30, 2020, in accordance with the CONSORT statement of the updated guidelines for reporting randomised clinical trials. There was a significant (p<0.001) reduction of 45.7% with Pro-argin, 37.6% with 8% strontium acetate, 18.1% with FCPS, and 15.2% with NaF-based dentifrices relative to baseline on SCASS after one-minute application on sensitive teeth. Both treatments showed clinically and statistically significant (p<0.001) relief in pain due to DH relative to baseline on immediate post-treatment observation, as shown in Table 3. Colgate SENSITIVE INSTANT Relief Repair & Prevent toothpaste with PRO-ARGIN Technology and Zinc provides clinically proven instant* and lasting sensitivity relief1-2 plus lasting gum protection3. Tandkrmen innehller zink fr att strka tandkttet och frhindra att tandkttet drar sig tillbaka, vilket r en av de vanligaste orsakerna till att . 0:00 / 0:30 Colgate Sensitive Pro-Relief Challenge Advert April 2012 178,990 views Mar 29, 2012 Take the Colgate Sensitive Pro-Relief Challenge to Show more 15 Dislike Share. The main etiological factors are abrasion and erosion that may or may not be associated with gingival recession in DH. Arshad, S., Zaidi, S.J.A. Dentine hypersensitivity (DH) is a chronic condition with acute, transient pain in non-carious teeth that originates in response to thermal stimuli such as hot or cold, chemicals like acidic or sweet or salt, and mechanical stimuli due to exposure to dentinal tubules without any apparent clinical disease [1]. Am J Dent. For best performance, keep cap closed when not in use. Colgate Sensitive Pro-Relief efektywnie i szybko znosi nadwraliwo zbw, zamyka kanaliki zbinowe w ktrych s zakoczenia nerww, dziki czemu blokuje bl. Layer T, Hughes N. Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity. J Clin Dent 2009; 20 (Spec Iss): 123-130. The dropouts of the participants at each efficacy interval may be considered the weakness of this trial that was due to COVID-19 lockdown. All the treatment groups showed statistically significant improvement in DH with p<0.001 relative to baseline at all time points. compared the Pro-Argin formulation with a calcium sodium phosphosilicate toothpaste, demonstrating 88% versus 50% occlusion respectively. blokerer jeblikkeligt smerter fra isninger. Google Scholar. SHOULD A PATIENT CONTINUE USING Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE ONCE THE DENTINE SENSITIVITY HAS GONE? Clinical efficacy of BioMin F, Colgate sensitive pro-relief and Sensodyne rapid action dentifrices in DH [Internet]. Mode of action studies on a new desensitizing dentifrice containing 8.0% arginine, a high cleaning calcium carbonate system and 1450 ppm fluoride. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth**. [41] was performed in 2017 and reported inappropriate statistical methodologies related to the normal distribution of data and equality of variances, along with lacking information in 77.1% of the thirty-five randomised trials on DH management. In our study, Pro-argin treatment revealed an immediate clinical reduction of 45.7% on SCASS, 56% on VAS used for mechanical stimuli, and 48.1% on VAS used for water jet stimuli in DH demonstrated in Tables 3, 5, and 6. 2023 BioMed Central Ltd unless otherwise stated. Gently removes stains and helps restore the natural whiteness of your teeth. However, there is a substantial possibility that these fluoridated dentifrices can reduce DH. J Clin Periodontol. Follow the directions for use. Colgate Sensitive Pro-Relief Enamel Rebuild also: Fights cavities Strengthens enamel Freshens breath Vegan . Pro-Argin technology helps to seal and repair . A study evaluating the efficacy of strontium acetate relative to arginine-based dentifrices was conducted by West et al. DH most commonly involves the facial surfaces of maxillary and mandibular permanent teeth. 4.2 5 0 221 221 Colgate Sensitive Pro-Relief Enamel Rebuild toothpaste helps instantly repair sensitive teeth and provides lasting protection against hypersensitivity. WHAT IS THE FLUORIDE CONTENT OF Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE? To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Colgate Sensitive Pro-Relief Whitening Toothpaste provides clinically proven instant and lasting relief for sensitive teeth. However, FCPS formulation showed 1% more improvement than Pro-argin and 7% more than strontium acetate-based dentifrices. For instant relief, apply directly to the sensitive tooth with finger tip, and massage gently for 1 minute, once a week or less frequently. # In-vitro study, actual confocal images after 5 treatments. Docimo R et al. Directions *For instant relief, apply directly to the sensitive tooth with fingertip, and massage gently for 60 seconds, one a week or less frequently **For lasting relief, apply to a gentle toothbrush making sure to brush all sensitive areas of the teeth. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. The New Colgate Sensitive Instant* Relief Repair & Prevent Toothpaste starts blocking sensitivity pain instantly*. 7 Ipsos, UK Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2 weeks trial, 192 respondents, 2016. No adverse events like gingival inflammation, bad taste, allergies, fluoride incompatibility, and dental or tongue stains were observed for all dentifrices. Participants were asked to pick up the envelope from the box. Besides, these findings of the current study could be related to previously conducted clinical trials indicating the better clinical effectiveness of Pro-argin than strontium acetate against air-blast and tactile stimulus after three days and one week of application [30, 31]. Pro-Argin technology is occlusive. Nachar Sinus Rinse System, 4pcs Professional Baby Nasal Irrigator Portable Infant Nose Cleaner Quick Rinse Device All Natural Relief - BPA Free More Convenient. In addition, they should be reproducible and clinically relevant to stimuli triggering pain in DH [35]. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth (with continued use twice a day). Colgate-Palmolive Company 2018. Desensitizing toothpastes depolarize the nerves to reduce pain signals to the brain, while occlusives block the dentin tubules to prevent painful stimuli affecting dentinal fluids. The authors declare that they have no competing interests (financial and non-financial) related to the article. was used for statistical analysis. Work with Colgate Professional to help provide better oral care to your patients. All authors read and approved the final manuscript. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. While 8% strontium acetate showed a greater clinical reduction in water jet stimulated DH on VAS than Pro-argin at all efficacy intervals, as demonstrated in Table 6. With regular use, it creates a long-lasting protective barrier that acts as a seal against sensitivity. The prime focus of treatment nowadays is based on the exploration of novel materials to remineralise the exposed tubular endings and mimic and restore the structure of the dentin [11]. Colgate SENSITIVE Instant(Pro) Relief Enamel Repair Toothpaste 75ml (Pck 4,6,12) 15.99 to 39.99. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. FCPS was incorporated in OTC dentifrice with calcium, low contents of fluoride, and high contents of phosphate ions. 2009;20 (Spec Iss):123130. All rights reserved. A systematic review. Yes, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste should be used for twice daily toothbrushing to provide ongoing relief from the pain of sensitive teeth. 90 sold. J Clin Periodontol 42 S17 (2015) 4. The limitation of our study is that fluoridated dentifrice was used as a control which, although regarded as not possessing any desensitising effects. IRB-1351/DUHS/Approval/2019/184. 2017;62(2):18691. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. [32] reported statistically significant improvement in mechanical stimulated DH with Pro-argin immediately after topical application relative to 8% strontium Acetate in 2016. After six weeks, FCPS-based dentifrices showed greater clinical efficacy with mean scores (1.801.73) than other treatment arms for waterjet stimulated DH. This trial was registered in an ICMJE approved registry at https://clinicaltrials.gov/) under protocol Identifier: NCT04249336 [19] following the CONSORT guidelines [20] for parallel-group randomized trials after approval from the Institutional Review Board of Dow University of Health Sciences with reference no. Docimo et al. Instant relief when applied directly to the sensitive tooth with the fingertip and gently massaged for 1 minute. PubMed However, there was no significant treatment difference between dentifrices containing Pro-argin and strontium acetate (p>0.05) at each efficacy interval. All rights reserved. The widely accepted hydrodynamic theory proposes that stimuli can alter the behavior of fluid in the dentin tubules, activating intra-dental nerve fibers and causing pain. 2020;99(5):51422. Gently and effectively removes stains. Book If the enamel is too thin, has tiny tubules that reveal the underlying dentin, or is worn down in some places. It has stannous fluoride as an active ingredient. Colgate Sensitive Instant* Relief Enamel Repair Toothpaste gives you clinically proven lasting relief** from sensitivity for 8 weeks when you use it twice a day. in 2019 using BioMin F and Pro-argin. *with direct application and daily brushing. Dentifrices were removed carefully after one minute of undisturbed application by rinsing the air lightly with an air syringe, and the subject was asked to spit. Balevi B. Product Benefits. Table 2 presents descriptive statistics of the primary analysis population as the primary statistical analysis was performed for 47 males and 81 females of age ranging from 18 to 50years with a mean age of 34.18.9. Compend Contin Educ Dent. statement and Soft tissues were isolated with cotton rolls, and adjacent teeth were isolated with cotton pellets. Pro-Argin technology can be found in Colgate Sensitive Pro Relief Toothpaste, sold as Colgate Sensitive Instant Relief in the UK and elmex Sensitive Professional in Europe. it is in a rubbish bin now. Not all desensitizing toothpastes perform equally well. Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Helps repair teeth by forming a mineral layer that re-constructs the sensitive part of the tooth, with regular use; Seals the open nerve channels for instant relief, and helps prevent sensitivity from re-occurring; Plus the freshness you trust from Colgate Plus it has the freshness you trust from Colgate! When you recommend Colgate Sensitive Pro Relief, you can help your dentin hypersensitivity patients to enjoy a pain-free life, confident in the knowledge that youre providing a highly effective, evidence-based solution. This clinical trial has not included a run-in or washout period before the test phase due to time constraints and compliance of the potential participants. 1,2 Int J Dent. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. Two double-blind randomized clinical studies by Nathoo et al. Mockdeci H, Polonini H, Martins I, Granato A-P, Raposo N. Evaluation of ex vivo effectiveness of commercial desensitizing dentifrices. Colgate* Sensitive Pro-Relief TM/MC Toothpaste with Pro-Argin TM/MC Technology is the first toothpaste that is clinically proven to provide instant & lasting relief from dentin hypersensitivity. Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults. Part of Nathoo S et al. J Clin Periodontol. Pro-Argin Technology with arginine and an insoluble calcium compound, zinc and 1450ppm fluoride. YYYY Colgate-Palmolive Company. Clinically proven Instant and lasting Sensitivity relief*. * For instant relief, apply directly to the sensitive tooth with finger tip and gently massage for 1 minute. 4Intervention D denotes Colgate Total. PubMedGoogle Scholar. Was this answer helpful? CONSORT flow chart. This clinical trial was not funded by any agency in public, commercial or not-for-profit sectors. Comparative evaluation of the efficacy of three commercially available toothpastes on dentin hypersensitivity reduction: an 8-week clinical study. For more great Dental Care products like toothpaste and mouthwash, continue browsing online and buy in-store at B&M. Colgate Sensitive Instant Relief Toothpaste 75ml Product code: 326795 2.49 Subject to availability - visit your nearest store It improves gum health and helps reduce factors that contribute to gum recession, a leading cause of tooth sensitivity. 2016;8:114. 2012;12(3):2208. Participantswere strictly advised to refrain from acidic food and drink intake at least four hours before following up visit. Most sensitive toothpastes primarily numb the discomfort, whereas Colgate Sensitive Pro-Relief works to relieve sensitivity by plugging the channels that lead to sensitive tooth nerves. 2017;457:2530. The second null hypothesis was that mean scores for pain due to DH among different treatment groups for sustained relief remains the same, and it was considered to be rejected at a p value0.05. The probable reason for variations between this clinical trial and previously conducted studies could be attributed to racial or ethnic differences between the conducted trials. J Clin Exp Dent. J Evid Based Dent Pract. Provides 24/7 sensitivity protection. Yang ZY, Wang F, Lu K, Li YH, Zhou Z. Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis. Colgate Sensitive Pro-relief Instant Relief. J Dent. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. These fluorapatite crystals were less susceptible to acidic dissolution than hydroxyapatite crystals and thus were more desirable [13]. 2018;2018:110. Holland G, Narhi M, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Hence, the current study outcomes, along with previously published findings, corroborate the in vitro findings of obliteration of dentinal tubules with strontium acetate impeding painful fluid movement in dentine [29]. Post-application changes on SCASS were observed after one minute, three days, two, four, and six weeks, subsequently. SA was the principal investigator and has contributed to design, data acquisition, analysis, and interpretation, and drafted the manuscript. . Then, the repeated measure was obtained after five minutes for previous pain recovery, and dentifrices were provided to the patient for self-application. Colgate SENSITIVE PRO-Relief has been rebranded to Colgate SENSITIVE INSTANT Relief . It also strengthens tooth enamel by helping rebuild weak spots. This study investigated the relief from pain in DH in one minute after applying over the counter (OTC) dentifrices with Pro-Argin and strontium acetate and directly compared them with fluoro-calcium phospho-silicate (FCPS)-based dentifrices for immediate and sustained inhibition of painful stimulus provoking DH. YES Somewhat No Therefore, the first null hypothesis was that mean scores for pain due to DH among different treatment groups for immediate relief remain. 2017;71:18. Published literature [16, 31, 43] has determined that all previous trials on treating DH were conducted on smaller samples, which might have prevented the results from being extrapolated on the general population. 1. J Dent. A total of 140 participants were initially enrolled and randomised into the four treatment arms, with thirty-five in each group. The clinical significance of this study can be highlighted by the fact that this was a person-centred clinical trial where patients were the prime focus where thepatients suffering from DH. Compend Contin Educ Dent. Colgate Sensitive Pro Relief offers a solution that is clinically proven to relieve sensitivity pain. In this way, variability in individuals' pain response was tried to be controlled and will be discussed in part 2 of this manuscript. The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. 4 Hines D et al. It uses an 8% arginine and calcium carbonate formulation to quickly seal the open dentin tubules, replicating and enhancing the natural mechanism of hypersensitivity relief. For lasting relief and gum protection, apply twice daily using a sensitive toothbrush, making sure to brush all surfaces of teeth including sensitive areas. Thank you for your feedback. Made by one of the best-known oral care companies in Australia, it has been clinically proven to provide both instantaneous and lasting relief from sensitivity, whilst also: Fighting cavities. It is clinically proven for instant and lasting Sensitivity relief* How does it work? Statistical Package for the Social Sciences software v.21.0. Free postage. Docimo R, Montesani L, Maturo P, Costacurta M, Bartolino M, DeVizio W, Zhang YP, Cummins D, Dibart S, Mateo LR: Comparing the Efficacy in Reducing Dentine Hypersensitivity of a New Toothpaste Containing 8.0% Arginine, Calcium Carbonate, and 1450 ppm Fluoride to a Commercial Sensitive Toothpaste Containing 2% Potassium Ion: An Eight-Week Clinical Study in Rome, Italy. Colgate Sensitive Instant Relief Toothpaste starts blocking sensitivity pain instantly*. How to use Listing a study does not mean it has been evaluated by the U.S. Federal Government. Colgate Professional has resources to help your patients understand what causes enamel erosion and how to avoid falling into those traps. Dent Health Curr Res. 2017;59(4):4618. Gillam D, Hill R, Samueli A. Bioactive glasses in the management of dentine hypersensitivity: a review. Colgate Sensitive Pro Relief can be applied directly to the affected area for almost instant relief. OTC dentifrices with Pro-argin and strontium acetate are effective for immediate pain relief from DH, and FCPS could be the best possible treatment option for long term management of DH. Find products and services. J Dent. Last updated on May 11, 2021. https://clinicaltrials.gov/ct2/show/NCT04249336. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. We discuss how this innovative technology works to provide patients with rapid and long-lasting relief from dentin hypersensitivity. Another . 2010;21(2):568. The loss of tooth enamel is the most common cause of tooth sensitivity and is not affected by cavities, gum disease, or other problems. All rights reserved. Poster #3406, July 2018 IADR. Lg i kurv. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Gentle whitening formula. However, Pro-argin formulation showed 8% more improvement in clinical symptoms of DH than strontium acetate formulation one minute after application. 2009;22(Spec No. J Clin Periodontol 42 (2015), 17, 4. Department of Oral Biology, Dr. Ishrat-Ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Dow University of Health Sciences, Karachi, Pakistan, Department of Oral Biology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan, Department of Research, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan, You can also search for this author in 2018. Madurai: Best Dental Science College; 2020. Am J Dent. Colgate Sensitive Pro-Relief (Toothpaste): 1.9 out of 5 stars from 91 genuine reviews on Australia's largest opinion site ProductReview.com.au. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. Therefore, it was considered to be rejected at a p valueof 0.05. Cite this article. Size: 75ml (Approx.) These measures facilitated behaviour modification together with the promotion of knowledge and understanding in the society about DH. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste for the daily oral care of patients with dentine hypersensitivity and gum problems. 2017;9(4):e503. Paired sample T-test was used to compute mean scores to observe change relative to baseline at each time point. J Dent Probl Solut. In addition, participants were asked to record the overall sensitivity of their day-to-day experience on provided VAS sheets reporting pain on brushing, taking hot or cold beverages, and rinsing with tap water for the six weeks of the study. If symptoms persist, talk to your healthcare professional. 2020;20(3):101460. and Ayad et al. [10] examined the evidence for strontium acetate and Pro-argin in 2018, and their findings depicted low quality of evidence for strontium acetate on the Grading of Recommendations, Assessment, Development, and Evaluations system (GRADE). [33] again reported a 54% clinical reduction in DH with Pro-argin in eight weeks clinical trial using SCASS. Formulated with Pro-Argin technology, Colgate Sensitive Pro-Relief is clinically proven instant and lasting sensitivity relief*. How does Colgate Sensitive Pro-Relief Repair & Prevent work? compared the Pro-Argin formulation with a calcium sodium phosphosilicate toothpaste, demonstrating 88% versus 50% occlusion respectively. Clinically proven amino acid formula with Pro-Argin technology to provide sensitivity relief. The Sensitive Pro-Relief Multi-Protection toothpaste by Colgate thoroughly cleans your teeth, while providing you with relief from sensitive tooth pain. Colgate Sensitive Pro-Relief Multi Protection Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. The treatment difference between Pro-argin and 8% strontium acetate was not statistically significant with a p>0.05 for immediate and sustained pain relief in DH and statistically significant relative to control on all clinical parameters of the SCASS and VAS. Colgate Sensitive Pro Relief Teeth Whitening Sensitivity Toothpaste, 75ml 4.9 out of 5 stars 12 7 offers from SAR 33.95 Colgate Sensitive Pro Relief Base Instant Sensitivity Relief Toothpaste, 75ml 4.3 out of 5 stars 20 5 offers from SAR 31.25 Colgate Total 12 hour Protection Pro - Gum Health Toothpaste 75ml Internal report 2018, 5.

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