The only way to remove broken hearts is by donating to a Confessional Machine, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Jacob & Esau, Holding the fire button charges up a light beam attack similar to Brimstone, The light beam deals damage equal to your current tear damage per tick to any enemies touching it, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Bethany, When picked up, this item gives you a stat increase, based on which is currently the lowest. poison effect for Pestilence, Added as part of the Afterbirth+ Booster Pack #3. Touching the white flame temporarily turns you into The Lost, but allows you to walk through the mirror into a mirrored version of this floor. The only way to remove it is via having a second trinket slot (Mom's Purse, Belly Button) or absorbing it (Marbles, Smelter, Gulp! ?, Satan and The Lamb as Tainted Lazarus, All new chests become locked Golden chests, UNLOCK: Unlock this trinket by defeating Isaac, ?? This means if you roll into The Lost, changing back to another character will leave you with only 1/2 of a soul heart, Cannot turn you into a character that isn't unlocked yet, Also includes Lazarus II (Lazarus' revived form) and Dark Judas (effect of Judas' Shadow), It's also possible that this item will pick the same character, making it seem like nothing happened, *, grey, gray, black, remote, zapper, changer, building, A one time use item that when used will explode all objects (i.e. UNLOCK: Unlock this trinket by collecting three of the following in the same run: Magic 8 Ball, Tiny Planet, Crystal Ball, Star of Bethlehem or any of the Astrology-related items (e.g. This spawns friendly charger enemies and causes Isaac to deal 5 contact damage (same as the shade did). This mod adds text to the screen that describes the effects of every item in the game - pedestal items,. If you touch an enemy in that time, Isaac will pick it up and slam it on the ground, killing it and sending a shockwave around the impact, In the brief period while holding the enemy you can move a target to decide where it lands, Actually does work on bosses! This room isn't part of the actual floor, and leaving it returns you to where you teleported from, The boss isn't necessarily from the current floor - e.g. Play The Binding of Isaac for free right now on Android. Item Pool: Item Room, Super Sloth Miniboss, Bomb Beggar, * boss rush pool, boss rush room, item room, treasure room, item room pool, bob sloth, All floors guaranteed to have an Arcade except the Chest & Dark Room floors, Judas - Gives a passive Book of Belial item similar to Book of Virtues. When this active item is used, it. The more you spend the higher the stat increase, Possible stats include Speed, Damage and Range, 15c items give all 3 stats: +1 Damage Up, +0.03 or +0.06 Speed Up, +0.25 or +0.5 Range Up, 5c items give 1 or 2 stats: +0.5 Damage Up **OR** +0.25 Range and +0.03 Speed Up, UNLOCK: Unlock this item by defeating Mother as The Keeper, While in a room with enemies, blue spiders will randomly spawn from objects in the room (e.g. Even though they look like reskins of Cain, Isaac, Lilith, and the rest, most of them start with new items and abilities, effectively doubling the way you can begin a new run once they're unlocked. REPENTANCE - The Lost's Holy Mantle can no longer be re-rolled using an item like D4. UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Bethany, Spawns a random pedestal item from the current room's item pool, In exchange, turns one heart container or 2 soul hearts into a broken heart. Half hearts heal a whole heart and full hearts heal 2 red hearts, UNLOCK: Unlock this item by beating Boss Rush with Maggy, * item room, treasure room, item room pool, the lost item pool, pink, purple, candy, Each time you enter a new room, damage is negated for the first time you get hit, Can be used to go in and out of a Curse Room without taking damage. item room pool, question mark book, white, When used, spawns 4-8 friendly blue spiders on the floor, REPENTANCE - Used to give 1-4 spiders per use, * item room, treasure room, item room poolgrey, gray, Allows you to fire a red flame infront of you, similar to the Blue Candle item, however the flame will stay 10 seconds, Each flame deals 125 total damage before it disappears, The flame will shrink in size when deals damage to something and eventually disappear, REPENTANCE - Red Candle flames now time out after ten seconds and automatically extinguish. The rock wave deals 10 damage. The mirrored floor rooms have respawned enemies, and allows you to optionally fight the Boss a second time for an extra item, When combined with Knife Piece 2, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, Combine with Knife Piece 1 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Mines/Ashpit II, there's a room with a minecart and a broken track. the lost item pool, grey, gray, A familiar which follows Isaac and shoots spectral tears that deal 3.5 damage, Ghost Baby fires tears at a rate of 1 tear per second, Can drop while destroying skulls in the Depths and Necropolis floors, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, white, spoopy, A spacebar item which allows Isaac to fire a blue flame that damages anything in its path for 23 damage per tick, Can cause up to a total of 276 potential damage, The flame destroys enemy shots, making it useful for bullet hell bosses, UNLOCK: Unlock this item by donating 900 coins to the Shop, * shop room pool, shop item pool, blue candle, grey, gray, silver, lamp, lantern, * boss room pool, boss room item, grey, gray, whip, cat o nine tails catonine tails, Upon use, re-rolls all pickup consumables in the current room into another random kind of pickup, This includes all types of pickup such as hearts, bombs, keys, coins, pills, tarot cards, chests, trinkets etc, UNLOCK: Unlock this item by beating the Chest with Isaac, * item room, treasure room, item room pool, dice pip, red, A familiar which follows Isaac and shoots two normal tears at once in a V-shaped pattern, Each of Harlequin Baby's tears deal 4 damage, Harlequin Baby fires tears at a rate of 1 tear per second, * item room, treasure room, item room pool, bug, eyes, pink, red, Tears now become missiles which deal huge damage to anything nearby, This item places a controllable red target on the ground which will cause a missile to fall from the sky and hit it after a short period of time, UNLOCK: Unlock this item by beating Challenge #19 (The Family Man), Item Pool: Secret Room Item Room (very low weight), * item room, treasure room, item room pool, fetus in a jar, bug, white, hat, pink, If a tear kills an enemy, it continues to travel forward with the leftover damage, * item room, treasure room, item room pool, large eye, cyclops, one eye, blue, white, A shadow follows Isaac and stomps on enemies randomly, dealing 40 damage per stomp (2 damage ticks at 20 damage each). ), Keeps the chance at 100% even after entering and leaving the angel room, meaning the door will not close after visiting, Makes it impossible to find Devil Rooms again, unless you find a way to remove or reroll this item away, or find the Duality item, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Maggy, A sack familiar that drops a sack every 5 or 6 rooms cleared (alternates between 5 and 6), UNLOCK: Unlock this item by defeating Greedier Mode as Cain, * back in black, ac/dc, bag, brown, pouch, pocket, bulge, Gives you an extra heart container for every 25 coins you are currently holding, up to a maximum of 4 extra HP at 99 coins held, If your coin counter goes below the required amount for a heart container, you will lose it again, This item works for the Keeper, allowing him to exceed his usual 2 health containers, However, if Keeper drops to under 2 health coins as a result of Greed's Gullet, he is unable to use a HP Up to increase his health back to 2, and has to regain the lost coins to do so, UNLOCK: Unlock this item by beating Challenge #35 (Pong), *, dollar, cash, sack, bag, pouch, greeds gullet, greed gullet, Gives you a random chance while firing tears to also fire a creep shot, which deals double your tear damage and places white creep on the floor infront of you that slows enemies down if they walk through it, Unlike some similar tear effects, your luck stat does not alter the chance for this effect to activate, A creep shot is also fired in a random direction after taking damage, While firing tears you have a 5% chance to fire a void tear. Enemies include Candler, Lil' Haunt, Polty, Red Ghost, Wizoob and The Forsaken, The Haunt, The Heretic and The Rainmaker bosses. Item Pool: Item Room Items that are better than the average and are good additions to have on most builds. Enemies are frozen in place while touching the yellow ring, Enemies touching the ring will stay permanently frozen until you move away, except for bosses which only get a temporary freeze effect after touching it, UNLOCK: Unlock this item by defeating Ultra Greedier as The Forgotten, When you pick this item up, the Mysterious Paper trinket is spawned on the ground, UNLOCK: Unlock this item by defeating Boss Rush as The Forgotten, A familiar that flies across the room every few seconds while firing and damages enemies (2x your tear damage), Can also be used like the Boomerang to pick up consumables on the ground, UNLOCK: Unlock this item by defeating ??? First ever time beating beast, and completing a list. In exchange it gives you +0.05 Speed Up and Damage Up for every half a heart this item removes, The amount of Damage Up is (0.15 * FullHeartsRemoved ^ 2), If Isaac is already at half a red heart when stabbed, no damage or speed increases are given, The damage from being stabbed can be avoided with invincibility, however no damage or speed stat increases are gained if you do, Your individual tears each gain a random effect from either: Poison, Fear, Slow, Freeze, Charm, Burning, Homing, Bleeding, x2 Damage or Reduced damage, Allows you to walk on harmful floor effects without taking damage (e.g. Kicking a frozen enemy will push it into the wall, where it shatters and fires ice shards everywhere (these can then freeze other enemies), Enemies touching the cube while it's not moving or moving slowly will become slowed for a few seconds, and take a small amount of damage, Cube Baby and enemies frozen will block enemy shots, Cube Baby can be launched across the room if you have a melee weapon, Enemies that die now spawn a red ghost, that floats in place of where the enemy died, Activating the item causes all red ghosts in the room to explode, dealing damage to any enemies near them, The explosion doesn't deal damage to Isaac, Damage dealt by each ghost is 3 + 0.04x the HP of the enemy it spawned from, Larger enemies such as minibosses will spawn a larger red ghost that causes 3 explosions, The red ghosts can be moved around slightly by firing tears through them, Using the item will instantly kill any enemy or boss that has the 'ghost' tag and is at 50% or less HP. with Lilith, After picking up 15 hearts, Isaac gains a permanent angelic familiar and a soul heart drops, Possible familiars include: Holy Water, Guardian Angel, Sworn Protector, The Relic and Seraphim, It is possible to get multiple followers by continuing to pick up hearts, at intervals of 15 hearts each, After all 5 familiars have spawned, it will just drop a soul heart every 15 hearts collected, UNLOCK: Unlock this item by beating Boss Rush with Lilith, Two items now spawn in each of your item rooms, however only one can be taken and the other will disappear, A crown that replaces normal tears with blue diamond tears while you don't have any empty red heart containers or bone hearts, While the effect is active, tears do double damage and have -0.30 Shot Speed, The crown will glow blue while active, if inactive it will appear grey, The effect will also deactivate for the rest of the current room when you take damage, regardless of your health, When a room clear would otherwise yield no rewards, it now spawns 1-3 pennies, REPENTANCE - Deep Pockets no longer adds a pill/card slot, instead increases money cap to 999, UNLOCK: Unlock this item by beating The Chest floor with Keeper, A flying familiar that bounces around the room with a damaging aura, dealing rapid damage to any enemies inside it and boosting Isaac's tear damage, While standing in the black aura, Isaac has a temporary 1.5x damage multiplier (this will stack if you have more than one Succubus), The aura deals 2.5 damage per tick or about 7.5 - 10 damage per second, UNLOCK: Unlock this item by beating The Lamb with Lilith, Gives you a different tear effect with every tear that you fire, Tear effects include: Anti-Gravity, Ball of Bandages (Lvl 4), Bumbo (Lvl 3), Continuum, Cupid's Arrow, Compound Fracture, Euthanasia, Explosivo, Eye of Greed, Fire Mind, Flat Stone, Flat Worm, God's Flesh, Godhead, Head of the Keeper, Holy Light, Hook Worm, Ipecac, Iron Bar, Jacob's Ladder, Knockout Drops, Lachryphagy, Little Horn, Lodestone, Mom's Contacts, Mom's Eyeshadow, Mom's Perfume, Mucormycosis, My Reflection, Mysterious Liquid, Ocular Rift, Ouija Board, Ouroboros Worm, The Parasite, Parasitoid, Polyphemus, Pop!, Proptosis, Pulse Worm, Ring Worm, Rotten Tomato, Rubber Cement, Serpent's Kiss, Sinus Infection, Spider Bite, Strange Attractor, Sulfuric Acid, Technology Zero, Tiny Planet, Trisagion and Wiggle Worm, With Dr. Fetus, this item will also cycle through random Bomb Modifiers (e.g. It's a 20% chance on first miss, 33% for a second miss and 50% for anything beyond that, Piercing shots work with this item and multiple hits with a single tear will each give a damage bonus, *, bullseye, target, grey, gray, black, red, circle, Isaac has a random chance to fire a Holy tear, which when it hits an enemy, will spawn a light beam on the same enemy, dealing damage, The beams from this item deal damage equal to 400% of your tear damage (4x damage multiplier for the beams only), The chance to fire a Holy tear is affected by your luck stat, maxing out at a 50% chance, Item Pool: Item Room, Greed Mode Item Room, Angel Room, A familiar host that sits on Isaac's head and has a 20% chance to block enemy shots, When a shot is blocked, Host Hat will fire 3 bullets back at the enemy, Causes you to become immune to explosions, but doesn't protect against stomps or shockwaves, Causes your shops to instantly restock their items when you buy them, New items generated by Restock are from the shop item pool, The cost increases exponentially every time you purchase an item. UNLOCK: Unlock this item by defeating Delirium in The Void floor with Isaac, A one time use active item that when used, will spawn 2 random item pedestals from the item pool associated with the current room (e.g. Based on the Steam Workshop mod (originally called Lightshot) created by Wyvern and TRPG, Pressing the CTRL key (R2 on PS4, RT on XB1, ZR on Switch) allows you to switch active items, Some items that give temporary effects like The Nail might deactivate if switched to the other slot, Added as part of the Afterbirth+ Booster Pack #4, UNLOCK: Unlock this item by entering every Shop from the first floor up to Mom's Foot (Depths 2) in one run, Grants you a shield when entering the Boss Room, which prevents damage from 1 hit, then disappears. If an enemy is killed while it is golden, it will drop between 1-4 coins, Contact damage is also dealt to enemies equal to the amount of coins Isaac is currently holding, Has a synergy with The Poop item, which gives it a high chance to spawn golden poops, * item room, treasure room, item room pool, gold, ingot, bar, orange, All future pennies, keys, bombs and hearts have a chance to drop in pairs, Does not work for other pickups, such as soul hearts, nickels, dimes, cards, pills etc, REPENTANCE - No longer guarantees all pickups to be doubled (is now chance-based), and doesn't change existing pickups that already dropped, * Humbling bundle shop room pool, shop item pool, paper, purple, brown, When you take damage, there is a 50% chance to drop a random heart, key, bomb or coin, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, bag, satchel, backpack, purse, satchel, brown, When your spacebar item is not fully charged, you can press spacebar to recharge it at the cost half of a heart per charge, Will not kill you if used - it stops a half a heart left, Red hearts are taken before other kinds, i.e. Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation. These will more than usually harm you than help you. Every playable character in The Binding of Isaac: Repentance has a "tainted" version. - The Binding Of Isaac: Repentance Ep. The Binding of Isaac is a randomly generated action RPG shooter with heavy Rogue-like elements. * boss room pool, boss room item, mr. squeezy, mr squeezy, cobaltstreak, white, brown, red, bow, * boss room pool, boss room item, purple, carton, grape drank, When picked up, spawns 1 red heart, 1 key, 1 bomb, 1 coin, 1 card/rune, 1 pill and 1 trinket, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, brown, orange, cardboard, Doubles the yield of hearts, coins, bombs and keys that spawn from non-red chests, Item Pool: Shop, Challenge Room, Key Beggar, Mom's Chest, * key master pool, key beggar pool, key judgement pool, , dungeon room, blood challenge room, arena pool, shop room pool, shop item pool, golden, horns, moms key, mom key, Tears have a random chance to charm enemies, Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac, The chance to charm enemies is affected by your luck stat and at +27 Luck it will activate every time, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, In-depth explanation of how the new Sacrifice room mechanics works in The Binding of Isaac: Afterbirth. The effect is weaker than normal runes. During this time he can walk over enemies to mark them for death. Shows you to see the contents of chests, sacks, shopkeepers and items that will drop from fires before you destroy them, Doesn't work on tinted rocks and other obstacles (e.g. knife, red, silver, Gives a 33% chance of converting red heart drops into soul hearts. When used, fills the entire room with poop! Tap the drop button to cycle between each one, All future pill drops will now instead become cards, * shop room pool, shop item pool, packet, deck, brown, orange, Allows for 2 pills to be held. Unlocked from Challenge #24 - PAY TO PLAY, Friends till the end - Spawns three friendly blue attack flies, Infested! It grows rapidly in size then explodes into a gas cloud that damages nearby enemies, When the explosion happens, more homing fungus tears fire out in random directions. The Binding of Isaac: Android Edition allows you to take it with you everywhere you go . Doors remain open when entering a room with enemies in it. ?, Keeper and The Forgotten, UNLOCK: Unlock this item by defeating The Beast as Samson, The first time you take damage in a room, Isaac will become a ghost and time will stop for 3 seconds, During this ghost effect, you gain flight, spectral tears and the damage from the next hit you take is negated, Isaac returns to his body if you either clear the room or take damage while in ghost form, Only happens once per room - taking damage a second time does not turn you into a ghost again, UNLOCK: Unlock this item by defeating The Beast as Lazarus, Your tears are replaced with a charge attack that fires a homing, spectral fetus, The fetus tears deal damage equal to 75% of your current tear damage while in contact with enemies, roughly 5 times per second, Can't be held down like normal charge attacks, they will release automatically at full charge, UNLOCK: Unlock this item by defeating The Beast as Lilith, Gives you a familiar that can be charged up to release a black ring, that damages any enemies that touch it with rapid hits (similar to Maw of the Void / Athame effects), The effect does a decent amount of damage, but doesn't scale with your damage upgrades, UNLOCK: Unlock this item by defeating The Beast as Azazel, While firing tears, you now charge up a poop attack for 3 seconds that when released, fires from Isaac's behind, The poop attack deals your current tear damage to any enemies caught in the blast. Using it with less than 5 coins does nothing, UNLOCK: Unlock this item by collecting 99 coins then spending all of them in the same run, Upon use, grants use of Brimstone for the current room, If used twice in the same room, the brimstone laser becomes massive and deals +1.8 more damage, Using it more than twice in the same room will give a damage increase each time, Upon use, displays a random fortune and has a chance to drop either a soul heart, a card (including dice shards), rune/soul stone or a trinket, Soul hearts and tarot cards are much more common than trinkets, With each tear fired, you have a chance to fire 1-3 extra tears in random directions, The extra tears scale with your other damage increasing items, Synergises with other items that replace your tears, like Brimstone or Technology, The chance to fire extra tears is not affected by luck, This item will fire electricity at nearby enemies, dealing roughly x0.75 of your tear damage rapidly, The electricity can chain up to 4 enemies if they are close enough, On floors with water on the ground (Downpour, Flooded Caves, Dross) this effect chain onto enemies further away than it normally would, Taking damage causes Isaac to fire a circle of 10 tears around him, each dealing 10 damage, After taking damage, you also gain a +1.2 Tears Up for the rest of the current room. The item called Zodiac does not count. debug 1 - Displays hitboxes of objects. blue, glow, arrow, cross, * astrology, astronomy, item room, treasure room, item room pool, cyan, black, blue, glow, n, tail, Leaves a trail of tears on the floor behind Isaac which damages enemies that walk over it for 2 damage per tick, REPENTANCE - Aquarius now synergizes with tear effects, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, blue, glow, You avoid taking damage once every room. Hook Worm, Wiggle Worm etc. There's Options, Double item room, Boss Rush) the Moving Box will pick only one of the items at random, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by HurleyFarrill, UNLOCK: Unlock this item by using Pandora's Box in the Dark Room floor, Your tears will now be connected together by beams of electricity which deals damage to enemies they hit, The lasers from this item deal 30% of your current damage stat, REPENTANCE - Technology Zero's lasers now deal 30% of the player's damage stat per tick (from 100%), UNLOCK: Unlock this item by having 2 technology items at once, *, black, white, grey, gray, round, circle, eye, key, hole, coin, slot, laser, Taking damage will spawn an orbital that rotates around Isaac, dealing contact damage to enemies and blocking enemy projectiles, A maximum of 3 Leprocy orbitals can be active at one time, Using the orbital to deal damage to enemies can cause it to break, Added as part of the Afterbirth+ Booster Pack #2. Magic Fingers ignores the +40 flat damage with Ipecac, removing the synergy between these two, * shop room pool, shop item pool, item room, treasure room, item room pool, tissue, The Knife Piece 1 is located in the Item Room in the mirrored area. 20 days ago. After a few seconds a huge missile hits the target and deals 20x your tear damage to anything nearby, Essentially a one-time use of the Epic Fetus item, * item room, treasure room, item room pool, grey, gray, robot, Isaac's tears now have a piercing effect which allows them to travel through enemies instead of breaking on hit, * item room, treasure room, item room pool, arrow, penetrative, penetrating shots, grey, gray, While you have this flame you also have that item's effect, The flame deals double your tear damage to any enemies that touch it, but if it takes too much damage the flame will disappear and you lose the item's effect, Wisps are randomly chosen from Item Room, Boss Room and Shop item pools, with a 25% chance to pick the same pool as the current room, UNLOCK: Unlock this item by defeating Delirium as Tainted Bethany, When used, removes half a heart of health and creates a clot familiar, Clot familiars follow Isaac's exact movements including flight, firing tears and tear effects, Holding down the swap button will cause all your clots to stay in place, Works differently as Tainted Eve - instead clots are created by firing for 2 seconds, down to a minimum of half a red heart. yellow, white, triangle, The three heart containers are pre-filled with red hearts, UNLOCK: Unlock this item by beating the Chest with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, real platinum god, the lost item pool, Enemy projectiles will now slowly curve away from Isaac and avoid hitting him, UNLOCK: Unlock this item by beating Dark Room with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, A familiar that follows Isaac and charges forwards very slowly, dealing 2.7 damage per tick to any enemies it comes into contact with, Almost identical to the Little Chubby familiar, but this one moves much more slowly and deals less damage, REPENTANCE - The damage tick rate on Big Chubby has been increased, Upon use, this item deals 9,999,999 damage to all enemies in the room and then kills you 3 seconds later, This is a single use active item, meaning it is destroyed after using it, Does not kill both phases of multi-phase bosses like Hush or Ultra Greed, If used to kill a boss, the kill still counts as a victory for post-it note completion marks, but the run will still get a game over, Delirium's death animation takes longer than 3 seconds, meaning you will die before it can count as a completion mark. In the burst of tears is a kidney stone which deals a lot of damage, REPENTANCE - Kidney Stone is no longer a speed downgrade, UNLOCK: Unlock this item by beating Challenge #29 (Onan's Streak), Upon use, fires a huge Mega Satan laser for 15 seconds, dealing your tear damage * 5 per tick to anything in its path and pushing Isaac back by the force, The laser persists for the entire 15 seconds even between rooms and floors, This item appears in the Devil Room but is weighted to be about 5 times rarer than all other devil room items, UNLOCK: Unlock this item by beating Mega Satan with every character, *, red, grey, gray, brown, black, red, eyes, A crown appears above your head and while at exactly 1 full red heart of health, you gain a +1.5 Range Up, +2.0 Tears Up and +0.20 Shot Speed Up, Any time your health changes to be not exactly 1 red heart you lose the effect. Re-rolled items pick from the current room's item pool, Isaac starts with this item after it is unlocked, UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby, * item room, treasure room, item room pool, dice pip, starting, pink, red, cube, Bombs now do 185 damage (up from 100) and have a larger blast radius, Has a chance to drop from the Super Wrath miniboss fight, REPENTANCE - Mr. Mega bombs buffed from 110 to 185 each, UNLOCK: Unlock this item by destroying 10 tinted rocks, Item Pool: Item Room, Bomb Beggar, Super Wrath Miniboss, * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, slackaholicus, grey, gray, face, Cuts Isaac's head from his body for the current room, allowing him to fly and leaving the decapitated body to run around attacking enemies for 5.5 damage per tick, * item room, treasure room, item room pool, scissors, cutters, snip, scissors, silver, grey, gray, All damage taken is reduced to half a heart, Damaged reduction is reduced from every source in the game except Devil Deals and health down pills, Does not prevent death (i.e. You may see more or less than this on the Found HUD overlay, however this number varies based on your other damage increasing items. treasure room, item room pool, yellow, golden, ring, circle, Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, item room, treasure room, item room pool, yellow, red, blue, medicine, jar, drug, moms bottle of pills, Tears now have a random chance to apply a poison effect, causing double your tear damage per tick to enemies over time, The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time, * item room, treasure room, item room pool, green, snot, booger, ball, slime, Isaac's tears now split into two upon contact with enemies or the environment, Tears that split off from the main tear do less damage (tear damage * 0.5), Tears can keep splitting if they still have range and damage above 1, UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head, * item room, treasure room, item room pool, pink, slug, bug, face, When used, replaces all pedestal items in the current room with another random item. This allows you to stay alive as long as you don't get hit during this 10 second period, After this effect occurs, it cannot activate again until Isaac gains a half or full Soul Heart or a Black Heart. item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Drops a random trinket on the floor when picked up, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag, All of Isaac's bombs now leave a poison effect on any enemies within the blast radius, As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick, Has a chance to drop from the Super Sloth miniboss fight.

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