wrist brachial index interpretation

2023-04-11 08:34 阅读 1 次

Wrist-brachial index The wrist-brachial index (WBI) is used to identify the level and extent of upper extremity arterial occlusive disease. Arterial occlusions were correctly identified in 94 percent of segments and the absence of a significant stenosis correctly identified in 96 percent of segments. Belch JJ, Topol EJ, Agnelli G, et al. Low calf pain Pressure gradient from the calf and ankle is indicative of infrapopliteal disease. 1533 participants with PAD diagnosed by a vascular specialist were prospectively recruited from four out-patient clinics in Australia. 2, 3 Later, it was shown that the ABI is an . This study aimed to assess the association of high ABPI ( 1.4) with cardiovascular events in people with peripheral artery disease (PAD). Two branches at the beginning of the deep palmar arch are commonly visualized in normal individuals. ), The normal ABI is 0.9 to as high as 1.3. Romano M, Mainenti PP, Imbriaco M, et al. For example, velocities in the iliac artery vary between 100 and 200 cm/s and peak systolic velocities in the tibial artery are 40 and 70 cm/s. endstream endobj 300 0 obj <. Under these conditions, duplex ultrasound can be used to distinguish between arteries and veins by identifying the direction of flow. A pulse Doppler also permits localization of Doppler shifts induced by moving objects (red blood cells). 0.97 c. 1.08 d. 1.17 b. ABI 0.90 is diagnostic of arterial obstruction. ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. The pulse volume recording (. A normal test generally excludes arterial occlusive disease. Repeat ABIs demonstrate a recovery to the resting, baseline ABI value over time. (D) The ulnar Doppler waveforms tend to be similar to the ones seen in the radial artery. Wolf EA Jr, Sumner DS, Strandness DE Jr. Surg Gynecol Obstet 1978; 146:337. Peripheral arterial disease: identification and implications. Decreased ankle/arm blood pressure index and mortality in elderly women. The ankle-brachial pressure index (ABPI) or ankle-brachial index (ABI) is the ratio of the blood pressure at the ankle to the blood pressure in the upper arm (brachium). InterpretationA normal response to exercise is a slight increase or no change in the ABI compared with baseline. (A) This continuous-wave Doppler waveform was obtained from the radial artery with the hand very warm and relaxed. Normal is about 1.1 and less . Color Doppler and duplex ultrasound are used in conjunction with or following noninvasive physiologic testing. Biphasic signals may be normal in patients older than 60 because of decreased peripheral vascular resistance; however, monophasic signals unquestionably indicate significant pathology. A normal arterial Doppler velocity waveform is triphasic with a sharp upstroke, forward flow in systole with a sharp systolic peak, sharp downstroke, reversed flow component at the end of systole, and forward flow in late diastole (picture 5) [43,44]. Condition to be tested are thoracic outlet syndrome and Raynaud phenomenon. Facial Muscles Anatomy. Peripheral arterial disease: therapeutic confidence of CT versus digital subtraction angiography and effects on additional imaging recommendations. The ABI can tell your healthcare provider: How severe your PAD is, but it can't identify the exact location of the blood vessels that are blocked or narrowed. Index values are calculated at each level. Interpreting the Ankle-Brachial Index The ABI can be calculated by dividing the ankle pressures by the higher of the two brachial pressures and recording the value to two decimal places. The effects of exercise on the cardiovascular system are discussed elsewhere. ABI = ankle/ brachial index. Then follow the axillary artery distally. Analogous to the ankle and wrist pressure measurements, the toe cuff is inflated until the PPG waveform flattens and then the cuff is slowly deflated. The ulnar artery feeding the palmar arch. Surg Forum 1972; 23:238. Mechanical compression in the thoracic outlet region, vasospasm of the digital arteries, trauma-related thrombi in the hand or wrist, arteritis, and emboli from the heart or from proximal arm aneurysms are pathologies to be considered when evaluating the upper extremity arteries. A 20 mmHg or greater reduction in pressure is indicative of a flow-limiting lesion if the pressure difference is present either between segments along the same leg or when compared with the same level in the opposite leg (ie, right thigh/left thigh, right calf/left calf) (figure 1). Pulsed-wave Doppler signals and angle-corrected Doppler waveforms are used to determine blood flow velocities at selected portions of the artery. MDCT compared with digital subtraction angiography for assessment of lower extremity arterial occlusive disease: importance of reviewing cross-sectional images. Starting on the radial side, the first branch is the princeps pollicis (not shown), which supplies the thumb. ), Evaluate patients prior to or during planned vascular procedures. Is there a temperature difference between hands or finger(s)? If you have solid blood pressure skills, you will master the TBPI with ease. In one prospective study, the four-cuff technique correctly identified the level of the occlusive lesion in 78 percent of extremities [32]. Interventional Radiology Sonographer Vascular Ultrasound case: Upper Extremity Arterial PVR, Segmental Pressures and wrist brachial index interpretation. Bowers BL, Valentine RJ, Myers SI, et al. Vogt MT, Cauley JA, Newman AB, et al. A normal toe-brachial index is 0.7 to 0.8. Criqui MH, Langer RD, Fronek A, et al. BMJ 1996; 313:1440. The right subclavian artery and the right CCA are branches of the innominate (right brachiocephalic) artery. A variety of noninvasive examinations are available to assess the presence, extent, and severity of arterial disease and help to inform decisions about revascularization. Radiology 2004; 233:385. Circulation. While listening to either the dorsalis pedis or posterior tibial artery signal with a continuous wave Doppler (picture 1) , insufflate the cuff to a pressure above which the audible Doppler signal disappears. 13.1 ). Values greater than 1.40 indicate noncompressible vessels and are unreliable. ABI >1.30 suggests the presence of calcified vessels, For patients with a normal ankle-brachial index (ABI) who have typical symptoms of claudication, we suggest exercise testing. A pressure gradient of 20 to 30 mmHg normally exists between the ankle and the toe, and thus, a normal toe-brachial index is 0.7 to 0.8. It is a test that your doctor can order if they are. A normal value at the foot is 60 mmHg and a normal chest/foot ratio is 0.9 [38,39]. 13.1 ). (See 'Other imaging'above. This is unfortunate, considering that approximately 75% of subclavian stenosis cases occur on the left side. We encourage you to print or e-mail these topics to your patients. Imaging the small arteries of the hand is very challenging for several reasons. The brachial artery continues down the arm to trifurcate just below the elbow into the radial, ulnar, and interosseous (or median) arteries. 30% in the brachial artery Extremity arterial injuries may be the result of blunt or penetrating trauma They may be threatening due to exsanguination, result in multi-organ failure due to near exsanguination or be limb threatening due to ischemia and associated injuries TYPES OF VESSEL INJURY There are 5 major types of arterial injury: The result is the ABI. The patients must rest for 15 to 30 minutes prior to measuring the ankle pressure. Normal, angle-corrected peak systolic velocities (PSVs) within the proximal arm arteries, such as the subclavian and axillary arteries, generally run between 70 and 120cm/s. The discussion below focuses on lower extremity exercise testing. Color Doppler imaging of a stenosis shows: (1) narrowing of the arterial lumen; (2) altered color flow signals (aliasing) at the stenosis consistent with elevated blood flow velocities; and (3) an altered poststenotic color flow pattern due to turbulent flow ( Fig. Relleno Facial. hbbd```b``"VHFL`r6XDL.pIv0)J9_@ $$o``bd`L?o `J ProtocolsThere are many protocols for treadmill testing including fixed routines, graded routines and alternative protocols for patients with limited exercise ability [36]. Steps for calculating ankle-brachial indices include, 1) determine the highest brachial pressure, 2) determine the highest ankle pressure for each leg, and 3) divide the highest ankle pressure on each side by the highest overall brachial pressure. (See "Clinical features, diagnosis, and natural history of lower extremity peripheral artery disease"and "Upper extremity peripheral artery disease"and "Popliteal artery aneurysm"and "Chronic mesenteric ischemia"and "Acute arterial occlusion of the lower extremities (acute limb ischemia)". (B) The ulnar artery can be followed into the palm as a single large trunk (C) where it curves laterally to form the superficial palmar arch. Not only are the vessels small, there are numerous anatomic variations. LEARNING OBJECTIVES/OUTCOMES After completing this continuing education activity, the participant will: 1. Normal continuous-wave Doppler waveforms have a high-impedance triphasic shape, characteristic of extremity arteries (with the limb at rest). Surgery 1995; 118:496. Upper extremity arterial anatomy. Decreased peripheral vascular resistance is responsible for the loss of the reversed flow component and this finding may be normal in older patients or reflect compensatory vasodilation in response to an obstructive vascular lesion. The percent stenosis in lower extremity native vessels and vascular grafts can be estimated (table 1). Symptoms vary depending upon the vascular bed affected, the nature and severity of the disease and the presence and effectiveness of collateral circulation. Note the absence of blood flow signals in the radial artery (, Subclavian stenosis. The relationship between calf blood flow and ankle blood pressure in patients with intermittent claudication. An extensive diagnostic workup may be required. Ankle brachial index (ABI) is a means of detecting and quantifying peripheral arterial disease (PAD). PURPOSE: . It then bifurcates into the radial artery and ulnar arteries. Met R, Bipat S, Legemate DA, et al. The four-cuff technique introduces artifact because the high-thigh cuff is often not appropriately 120 percent the diameter of the thigh at the cuff site. 13.13 ). The level of TcPO2that indicates tissue healing remains controversial. Menke J, Larsen J. Meta-analysis: Accuracy of contrast-enhanced magnetic resonance angiography for assessing steno-occlusions in peripheral arterial disease. Circulation 1995; 92:614. Prevalence of elevated ankle-brachial index in the United States 1999 to 2002. Record the blood pressure of the DP artery. Circulation 2006; 113:e463. The lower the ABI, the more severe PAD. Surgery 1972; 72:873. The radial or ulnar arteries may have a supranormal wrist-brachial index. These articles are written at the 10thto 12thgrade reading level and are best for patients who want in-depth information and are comfortable with some medical jargon. The normal value for the WBI is 1.0. Finger Pressure Digit-Brachial Index (DBI) is the upper extremity equivalent of the lower extremity Ankle-Brachial Index. This reduces the blood pressure in the ankle. (See 'Digit waveforms'above. Color Doppler ultrasound is used to identify blood flow within the vessels and to give the examiner an idea of the velocity and direction of blood flow. Ankle-brachial index is calculated as the systolic blood pressure obtained at the ankle divided by the systolic blood pressure obtained at the brachial . (You can also locate patient education articles on a variety of subjects by searching on patient info and the keyword(s) of interest.). Facial Esthetics. These two arteries sometimes share a common trunk. Murabito JM, Evans JC, Larson MG, et al. The ankle-brachial index (ABI) is the ratio of the systolic blood pressure (SBP) measured at the ankle to that measured at the brachial artery. To investigate the repercussions of traumatic brachial plexus injury (TBPI) on diaphragmatic mobility and exercise capacity, compartmental volume changes, as well as volume contribution of each hemithorax and ventilation asymmetry during different respiratory maneuvers, and compare with healthy individuals. To differentiate from pseudoclaudication (atypical symptoms). Mild disease is characterized by loss of the dicrotic notch and an outward bowing of the downstroke of the waveform (picture 3). Thrombus or vasculitis can be visualized directly with gray-scale imaging, but color and power Doppler imaging are used to determine vessel patency and to assess the degree of vessel recanalization following thrombolysis. The ankle brachial index is lower as peripheral artery disease is worse. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Real-time ultrasonography uses reflected sound waves (echoes) to produce images and assess blood velocity. It is a screen for vascular disease. Available studies include physiologic tests that correlate symptoms with site and severity of arterial occlusive disease, and imaging studies that further delineate vascular anatomy. ), Contrast arteriography remains the gold standard for vascular imaging and, under some circumstances (eg, acute ischemia), is the primary imaging modality because it offers the benefit of potential simultaneous intervention. N Engl J Med 2001; 344:1608. Once you know you have PAD, you can repeat the test to see how you're doing after treatment. The anatomy as shown in this chapter is sufficient to perform a comprehensive examination of the upper extremity arteries. 13.3 and 13.4 ), axillary ( Fig. J Vasc Surg 2007; 45 Suppl S:S5. O'Hare AM, Katz R, Shlipak MG, et al. The upper extremity arterial system requires a different diagnostic approach than that used in the lower extremity. The formula used in the ABI calculator is very simple. The ratio of the velocity of blood at a suspected stenosis to the velocity obtained in a normal portion of the vessel is calculated. J Vasc Surg 1993; 17:578. O'Hare AM, Rodriguez RA, Bacchetti P. Low ankle-brachial index associated with rise in creatinine level over time: results from the atherosclerosis risk in communities study. Resnick HE, Lindsay RS, McDermott MM, et al. The ABI is generally, but not absolutely, correlated with clinical measures of lower extremity function such as walking distance, speed of walking, balance, and overall physical activity [13-18]. This is a situation where a tight stenosis or occlusion is present in the subclavian artery proximal to the origin of the vertebral artery (see Fig. An abnormal ankle-brachial index ( ABI 0.9) has an excellent overall accuracy for Diagnostic evaluation of lower extremity chronic venous insufficiency evaluation for peripheral artery disease (PAD) using the ankle-brachial index ( ABI ). Visceral arteries Duplex examination of visceral arteries, especially the renal arteries, requires the use of low frequency transducers to penetrate to the depth of these vessels. The ABI (or the TBI) is one of the common first This simple set of tests can answer the clinical question: Is hemodynamically significant arterial obstruction present in a major arm artery? 2012 Dec 11;126 (24):2890-909. doi: 10.1161/CIR.0b013e318276fbcb. INDICATIONS: Diabetes Care 2008; 31 Suppl 1:S12. An absolute toe pressure >30 mmHg is favorable for wound healing [28], although toe pressures >45 to 55 mmHg may be required for healing in patients with diabetes [29-31]. (See "Nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy in advanced renal failure", section on 'Gadolinium'.). The ankle brachial index is associated with leg function and physical activity: the Walking and Leg Circulation Study. Other studies frequently used to image the vasculature include computed tomography (CT) and magnetic resonance (MR) imaging. In addition to measuring toe systolic pressures, the toe Doppler arterial waveforms should also be evaluated. yr if P!U !a Exercise testing is generally not needed to diagnose upper extremity arterial disease, though, on occasion, it may play a role in the evaluation of subclavian steal syndrome. AbuRahma AF, Khan S, Robinson PA. Zierler RE. J Vasc Surg 1993; 18:506. The continuous wave hand-held ultrasound probe uses two separate ultrasound crystals, one for sending and one for receiving sound waves. Symptoms vary depending upon the vascular bed affected, the nature and severity of the disease and the presence and effectiveness of collateral circulation. Hiatt WR, Hirsch AT, Regensteiner JG, Brass EP. Successful visualization of a proximal subclavian stenosis is more likely on the right side, as shown in Fig. Subclavian occlusive disease. Compared with the cohort with an index >0.9, this group had markedly increased relative risks of 3.1 and 3.7 for death and coronary heart disease, respectively, at four years [, In a report from the Framingham study of 251 men and 423 women (mean age 80 years), 21 percent had an ABI <0.9 [, In a study of 262 patients, the ankle brachial index was measured in patients with type 2 diabetes [, The Multi-Ethnic Study of Atherosclerosis (MESA) study evaluated 4972 patients without clinical cardiovascular disease and found a greater left ventricular mass index in patients with high ABI (>1.4) compared with normal ABI (90 versus 72 g/m2) [, The Strong Heart Study followed 4393 Native American patients for a mean of eight years [. B-mode imagingThe B-mode provides a grey scale image useful for evaluating anatomic detail (picture 4). AJR Am J Roentgenol 2004; 182:201. Radiology 2000; 214:325. 2012; 126:2890-2909. doi: 10.1161/CIR.0b013e318276fbcb Link Google Scholar; 15. Only tests that confirm the presence of arterial disease,further define the level and extent of vascular pathologyor provide information that will alter the course of treatment should be performed.Vascular testing may be indicated for patients with suspected arterial disease based upon symptoms (eg, intermittent claudication), physical examination findings (eg, signs of tissue ischemia), or in patients who are asymptomatic with risk factors for atherosclerosis (eg, smoking, diabetes mellitus) or other arterial pathology (eg, trauma, peripheral embolism) [1]. 13.18 ) or on Doppler spectral waveforms at the level of occlusion, and a damped, monophasic Doppler signal distal to the obstruction (see Fig. The first step is to ask the patient what his/her symptoms are: Is there pain, and if so, how long has it been present? A >30 mmHg decrement between the highest systolic brachial pressure and high-thigh pressure is considered abnormal. (A) Following the identification of the subclavian artery on transverse plane (see. The axillary artery courses underneath the pectoralis minor muscle, crosses the teres major muscle, and then becomes the brachial artery. One or all of these tools may be needed to diagnose a given problem. Indications involved soft-tissue coverage of the elbow (n = 11), dorsal wrist and hand (n = 24), palmar wrist and hand (n = 12), and thumb amputations (n = 5); after release of thumb-index finger . S Angel Nursing School Studying Nursing Career Nursing Tips Nursing Notes Ob Nursing Child Nursing Nursing Programs Lpn Programs Funny Nursing Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study. The WBI for each upper extremity is calculated by dividing the highest wrist pressure (radial artery or ulnar artery) by the higher of the two brachial artery pressures. The resting systolic blood pressure at the ankle is compared with the systolic brachial pressure and the ratio of the two pressures defines the ankle-brachial (or ankle-arm) index. A metaanalysis of eight studies compared continuous versus graded routines in 658 patients in whom testing was repeated several times [. No differences between the injured and uninjured sides were observed with regard to arm circumference, arm length, elbow motion, muscle endurance, or grip strength. Different velocity waveforms are obtained depending upon whether the probe is proximal or distal to a stenosis. (See "Basic principles of wound management"and "Techniques for lower extremity amputation".). Signs [ edit ] Pallor Diminished pulses (distal to the fistula) Necrosis [1] Decreased wrist- brachial index (ratio of blood pressure measured in the wrist and the blood pressure [en.wikipedia.org] Physical examination findings may include unilaterally decreased pulses on the affected side, a blood pressure difference of greater than 20 mm Hg . Three patients with an occluded brachial artery had an abnormal wrist brachial index (0.73, 0.71, and 0.80). In general, only tests that confirm the presence of arterial disease or provide information that will alter the course of treatment should be performed. A more severe stenosis will further increase systolic and diastolic velocities. It is often quite difficult to obtain ankle-brachial index values in patients with monophasic continuous wave Doppler signals. (A) Anatomic location of the major upper extremity arteries. For instance, if fingers are cool and discolored with exposure to cold but fine otherwise, the examination will focus on the question of whether this is a vasospastic disorder (e.g., Raynaud disease) versus a situation where arterial obstructive disease is present. A normal value at the foot is 60 mmHg and a normal chest/foot ratio is 0.9. Given that interpretation of low flow velocities may be cumbersome in practice, it . ), An ABI 0.9 is diagnostic of occlusive arterial disease in patients with symptoms of claudication or other signs of ischemia and has 95 percent sensitivity (and 100 percent specificity) for detecting arteriogram-positive occlusive lesions associated with 50 percent stenosis in one or more major vessels [, An ABI of 0.4 to 0.9 suggests a degree of arterial obstruction often associated with claudication [, An ABI below 0.4 represents multilevel disease (any combination of iliac, femoral or tibial vessel disease) and may be associated with non-healing ulcerations, ischemic rest pain or pedal gangrene. Left ABI = highest left ankle systolic pressure / highest brachial systolic pressure. The walking distance, time to the onset of pain, and nature of any symptoms are recorded. Three other small digital arteries (not shown), called the palmar metacarpals, may be seen branching from the deep palmar arch, and these eventually join the common digital arteries to supply the fingers (see, The ulnar artery and superficial palmar arch examination. A difference of 20mm Hg between levels in the same arm is believed to represent evidence of disease although there are no large studies to support this assertion. Complete examination involves the visceral aorta, iliac bifurcation, and iliac arteries distally. J Vasc Surg 1996; 24:258. ), Physiologic tests include segmental limb pressure measurements and the determination of pressure index values (eg, ankle-brachial index, wrist-brachial index, toe-brachial index), exercise testing, segmental volume plethysmography, and transcutaneous oxygen measurements. MRA is usually only performed if revascularization is being considered. During the diagnostic procedure, your provider will compare the systolic blood pressure in your legs to the blood pressure in the arms. Velocity ratios >4.0 indicate a >75 percent stenosis in peripheral arteries (table 1). 13.20 ). PPG waveforms should have the same morphology as lower extremity wavforms, with sharp upstroke and dicrotic notch. Segmental pressuresOnce arterial occlusive disease has been verified using the ankle-brachial index (ABI) measurements (resting or post-exercise) (see 'Exercise testing'below), the level and extent of disease can be determined using segmental limb pressures which are performed using specialized equipment in the vascular laboratory. For patients with limited exercise ability, alternative forms of exercise can be used. The absolute value of the oxygen tension at the foot or leg, or a ratio of the foot value to chest wall value can be used. A three-cuff technique uses above knee, below knee, and ankle cuffs. Systolic blood pressure is the pressure on the walls of the blood vessels when the heart . (B) Sample the distal brachial artery at this point, just below the elbow joint (. (See 'Ankle-brachial index'above and 'Wrist-brachial index'above.). 13.18 . The measured blood pressures should be similar side to side, and from one level to the other (see Fig. 13.5 ), brachial ( Figs. 13.18 ). Noninvasive localization of arterial occlusive disease: a comparison of segmental Doppler pressures and arterial duplex mapping. (C) The ulnar artery starts by traveling deeply in the flexor muscles and then runs more superficially, along the volar aspect of the ulnar (medial) side of the forearm. PASCARELLI EF, BERTRAND CA. The principal anthropometry measures are the upper arm length, the triceps skin fold (TSF), and the (mid-)upper arm circumference ((M)UAC).The derived measures include the (mid-)upper arm muscle area ((M)UAMA), the (mid-)upper arm fat area ((M)UAFA), and the arm fat index. JAMA 1993; 270:465. Quantitative segmental pulse volume recorder: a clinical tool. The upper extremity arterial system takes origin from the aortic arch ( Fig. ULTRASOUNDUltrasound is the mainstay for noninvasive vascular imaging with each mode (eg, B-mode, duplex) providing specific information. 332 0 obj <>stream If the fingers are symptomatic, PPGs (see Fig. Deflate the cuff and take note when the whooshing sound returns. (A) After evaluating the radial artery and deep palmar arch, the examiner returns to the antecubital fossa to inspect the ulnar artery. Because of the multiple etiologies of upper extremity arterial disease, consider: to assess the type and duration of symptoms, evidence of skin changes and differences in color. TBI is a common vascular physiologic assessment test taken to determine the existence and severity of peripheral arterial disease (PAD) in the lower extremities. The frequency of ultrasound waves is 20000 Olin JW, Kaufman JA, Bluemke DA, et al. The pedal vessel (dorsalis pedis, posterior tibial) with the higher systolic pressure is used, and the pressure that occludes the pedal signal for each cuff level is measured by first inflating the cuff until the signal is no longer heard and then progressively deflating the cuff until the signal resumes. What makes the pain or discomfort better or worse? The lower the ABI, the more severe the PAD. Pressure gradient from the lower thigh to calf reflects popliteal disease. Upon further questioning, he is right-hand dominant and plays at the pitcher position in his varsity baseball team. Lower extremity segmental pressuresThe patient is placed in a supine position and rested for 15 minutes. However, the introduction of arterial evaluations for dialysis fistula placement and evaluation, radial artery catheterization, and radial artery harvesting for coronary artery bypass surgery or skin flap placement have increased demand for these tests. J Gen Intern Med 2001; 16:384. Circulation 2004; 109:2626. Duplex ultrasonography has gained a prominent role in the noninvasive assessment of the peripheral vasculature overcoming the limitations (need for intravenous contrast) of other noninvasive methods and providing precise anatomic localization and accurate grading of lesion severity [40,41].

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